|Statement||A. P. L. Blakely and John F. Wilkinson.|
|Contributions||Wilkinson, John F.|
|The Physical Object|
|Pagination||p. 349-354 ;|
|Number of Pages||354|
Abstract. The powerful effect of histamine as a stimulant of gastric secretion was discovered by Popielski and by Keeton, Luckhardt and Koch in – in experiments on dogs. A similar action in humans was demonstrated (Carnot et al., ) soon thereafter, and it was subsequently shown that histamine stimulates gastric secretion in all species adequately tested, including the groundhog Cited by: 7. Histamine sulfate and picrate were isolated from pigs' pyloric mucosa by a method described and histamine appeared to be the only gastric secretory excitant which can be extracted by acid from pyloric mucous membrane. Histamine, pilocarpine, and isopilocarpine were the only imidazoles out of 10 tried which stimulate gastric by: Histaminase or Diamine Oxidase is Absent From Gastric Mucosa. Histamine is Present in Gastric Juice. Is Histamine Absent From the Blood During Gastric Secretion? Histamine is Found in the Urine During Gastric Secretion. Stimulation of Gastric Secretion by Release of Histamine. Conclusion: Stimulation of Gastric Secretion is a Physiological Cited by: Two extremely different types of gastric juice are obtained (a) after subcutaneous administration of histamine, and (b) after sham‐feeding or pilocarpine injection. 2. There is little difference in the total chloride concentration and the total acidity of the gastric secretion provoked by sham‐feeding as compared with that provoked by.
2. This difference in the effect of histamine on pepsin output in man and dogs is probably a true species difference. If pepsin is secreted continuously, the low or absent basal secretion in the dog makes a washing out effect theoretically possible. Also, there is evidence that histamine may inhibit the action of the peptic cells of the dog. Histamine, discovered in by the British physiologist Sir Henry H. Dale, has become one of the most important biogenic amines in medicine and biology. In addition to the three well-known functions such as the contraction of smooth muscles, the increase in vascular permeability, and the stimulation of gastric acid secretion, histamine has been known to play various roles in. Gastric secretion. Results of opiates on secretory activity of the digestive glands gave conflicting results. Although most pharmacology text books (Jaffe and Martin ) describe opiates as inhibitors of gastric secretion. There have been some reports indicating that morphine and realted drugs may, in fact, increase gastric secretion. A much more powerful inhibition of gastric acid secretion (up to 99% inhibition) can be achieved with the newer proton pump inhibitors, developed and marketed from the late s and onwards. Proton pump inhibitors intercept the secretion of gastric acid from the parietal cells at a different stage of the process.
Mobilization and formation of histamine in the gastric mucosaas related toacid ol (Lond) ; 10 MacIntosh FC. Histamine as a normal stimulant of gastric secretion. QJExpPhysiol ; 11 CodeCF. Histamineandgastric secretion. In: Wolstenholme GEW,O'ConnorCM,eds. CibaFoundationsymposiumon histamine. The stomach is an ideal organ to study because the gastric juice kills most of the swallowed microbes and, thus, creates rather similar milieu among individuals. Combined with a rather easy access to gastric juice, gastric physiology was among the first areas to be studied. During the last century, a rather complete understanding of the regulation of gastric acidity was obtained, . "Histamine poisoning" can happen if you eat fish that weren't kept at safe temperatures and spoiled before you got them. Those fish can build up high levels of histamines, which can make you sick. In the routine histamine test of gastric secretion the dose of histamine advised has been determined arbitrarily as being generally sufficient to provoke an acid response and generally free from liability to cause untoward symptoms. It is thus a compromise, and fails to take account of individual variations in susceptibility. This defect .